Ontology highlight
ABSTRACT:
SUBMITTER: Jena B
PROVIDER: S-EPMC2938125 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Jena Bipulendu B Dotti Gianpietro G Cooper Laurence J N LJ
Blood 20100503 7
Infusions of antigen-specific T cells have yielded therapeutic responses in patients with pathogens and tumors. To broaden the clinical application of adoptive immunotherapy against malignancies, investigators have developed robust systems for the genetic modification and characterization of T cells expressing introduced chimeric antigen receptors (CARs) to redirect specificity. Human trials are under way in patients with aggressive malignancies to test the hypothesis that manipulating the recip ...[more]