Ontology highlight
ABSTRACT:
SUBMITTER: Conze T
PROVIDER: S-EPMC2938221 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Conze Tim T Göransson Jenny J Razzaghian Hamid Reza HR Ericsson Olle O Oberg Daniel D Akusjärvi Göran G Landegren Ulf U Nilsson Mats M
Nucleic acids research 20100629 16
Alternative splicing creates diverse mRNA isoforms from single genes and thereby enhances complexity of transcript structure and of gene function. We describe a method called spliceotyping, which translates combinatorial mRNA splicing patterns along transcripts into a library of binary strings of nucleic acid tags that encode the exon composition of individual mRNA molecules. The exon inclusion pattern of each analyzed transcript is thus represented as binary data, and the abundance of different ...[more]