Ontology highlight
ABSTRACT:
SUBMITTER: Cherny D
PROVIDER: S-EPMC2905242 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Cherny Dmitry D Gooding Clare C Eperon Giles E GE Coelho Miguel B MB Bagshaw Clive R CR Smith Christopher W J CW Eperon Ian C IC
The EMBO journal 20100525 13
Splicing is regulated by complex interactions of numerous RNA-binding proteins. The molecular mechanisms involved remain elusive, in large part because of ignorance regarding the numbers of proteins in regulatory complexes. Polypyrimidine tract-binding protein (PTB), which regulates tissue-specific splicing, represses exon 3 of alpha-tropomyosin through distant pyrimidine-rich tracts in the flanking introns. Current models for repression involve either PTB-mediated looping or the propagation of ...[more]