Ontology highlight
ABSTRACT:
SUBMITTER: Kolitz JE
PROVIDER: S-EPMC2938834 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Kolitz Jonathan E JE George Stephen L SL Marcucci Guido G Vij Ravi R Powell Bayard L BL Allen Steven L SL DeAngelo Daniel J DJ Shea Thomas C TC Stock Wendy W Baer Maria R MR Hars Vera V Maharry Kati K Hoke Eva E Vardiman James W JW Bloomfield Clara D CD Larson Richard A RA
Blood 20100603 9
Cancer and Leukemia Group B 19808 (CALGB 19808) is the only randomized trial of a second-generation P-glycoprotein (Pgp) modulator in untreated patients with acute myeloid leukemia (AML) younger than age 60 years. We randomly assigned 302 patients to receive induction chemotherapy regimens consisting of cytosine arabinoside (Ara-C; A), daunorubicin (D), and etoposide (E), without (ADE) or with (ADEP) PSC-833 (P). The incidence of complete remission was 75% with both regimens. Reversible grade 3 ...[more]