Ontology highlight
ABSTRACT:
SUBMITTER: Togasaki E
PROVIDER: S-EPMC5436079 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Togasaki E E Takeda J J Yoshida K K Shiozawa Y Y Takeuchi M M Oshima M M Saraya A A Iwama A A Yokote K K Sakaida E E Hirase C C Takeshita A A Imai K K Okumura H H Morishita Y Y Usui N N Takahashi N N Fujisawa S S Shiraishi Y Y Chiba K K Tanaka H H Kiyoi H H Ohnishi K K Ohtake S S Asou N N Kobayashi Y Y Miyazaki Y Y Miyano S S Ogawa S S Matsumura I I Nakaseko C C Naoe T T
Blood cancer journal 20170428 4
Although tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of chronic myeloid leukemia (CML), the ability of TKIs to eradicate CML remains uncertain and patients must continue TKI therapy for indefinite periods. In this study, we performed whole-exome sequencing to identify somatic mutations in 24 patients with newly diagnosed chronic phase CML who were registered in the JALSG CML212 study. We identified 191 somatic mutations other than the BCR-ABL1 fusion gene (median ...[more]