Unusual antimalarial meroditerpenes from tropical red macroalgae.
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ABSTRACT:
SUBMITTER: Stout EP
PROVIDER: S-EPMC2939151 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
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Unusual antimalarial meroditerpenes from tropical red macroalgae.
Stout E Paige EP Prudhomme Jacques J Roch Karine Le KL Fairchild Craig R CR Franzblau Scott G SG Aalbersberg William W Hay Mark E ME Kubanek Julia J
Bioorganic & medicinal chemistry letters 20100810 19
Three antimalarial meroditerpenes have been isolated from two Fijian red macroalgae. The absolute stereochemistry of callophycolide A (1), a unique macrolide from Callophycus serratus, was determined using a combination of Mosher's ester analysis, circular dichroism analysis with a dimolybdenum tetraacetate complex, and conformational analysis using NOEs. In addition, two known tocopherols, β-tocopherylhydroquinone (4) and δ-tocopherylhydroquinone (5), were isolated from Amphiroa crassa. By oxid ...[more]
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