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Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus.

ABSTRACT: Bromophycolides J-Q (1-8) were isolated from extracts of the Fijian red alga Callophycus serratus and identified with 1D and 2D NMR spectroscopy and mass spectral analyses. These diterpene-benzoate macrolides represent two novel carbon skeletons and add to the 10 previously reported bromophycolides (9-18) from this alga. Among these 18 bromophycolides, several exhibited activities in the low micromolar range against the human malaria parasite Plasmodium falciparum.

SUBMITTER: Lane AL 

PROVIDER: S-EPMC2707147 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus.

Lane Amy L AL   Stout E Paige EP   Lin An-Shen AS   Prudhomme Jacques J   Le Roch Karine K   Fairchild Craig R CR   Franzblau Scott G SG   Hay Mark E ME   Aalbersberg William W   Kubanek Julia J  

The Journal of organic chemistry 20090401 7

Bromophycolides J-Q (1-8) were isolated from extracts of the Fijian red alga Callophycus serratus and identified with 1D and 2D NMR spectroscopy and mass spectral analyses. These diterpene-benzoate macrolides represent two novel carbon skeletons and add to the 10 previously reported bromophycolides (9-18) from this alga. Among these 18 bromophycolides, several exhibited activities in the low micromolar range against the human malaria parasite Plasmodium falciparum. ...[more]

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