The Yin and Yang of bone morphogenetic proteins in cancer.
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ABSTRACT:
SUBMITTER: Singh A
PROVIDER: S-EPMC2939311 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
The Yin and Yang of bone morphogenetic proteins in cancer.
Singh Ashok A Morris Rebecca J RJ
Cytokine & growth factor reviews 20100804 4
Bone morphogenetic proteins (BMPs) were first studied as growth factors or morphogens of the transforming growth factor-beta superfamily. These growth molecules, originally associated with bone and cartilage development, are now known to play an important role in morphogenesis and homeostasis in many other tissues. More recently, significant contributions from BMPs, their receptors, and interacting molecules have been linked to carcinogenesis and tumor progression. On the other hand, BMPs can so ...[more]
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