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Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.


ABSTRACT:

Background

Malignant pleural mesothelioma (MPM) is a rare but fatal tumour. Although most MPM patients show pleural effusion at even the early stage, it is hard to diagnose as MPM at the early stage because a sensitive and reliable diagnostic marker for MPM has not been found in plasma or pleural effusion.

Methods

In this study, we investigated whether intelectin-1 was specifically contained in MPM cells and the pleural effusion of MPM patient by immunohistochemistry, western blotting, and enzyme-linked immunosorbent assay.

Results

Malignant pleural mesothelioma cell lines, but not lung adenocarcinoma cell lines, secreted intelectin-1. In immunohistochemistry, epithelioid-type MPMs, but neither pleura-invading lung adenocarcinomas nor reactive mesothelial cells near the lung adenocarcinomas, were stained with anti-intelectin antibodies. Pleural effusion of MPM patients contained a higher concentration of intelectin-1 than that of lung cancer patients.

Conclusion

These results suggest that detection of intelectin-1 may be useful for a differential diagnosis of epithelioid-type MPM in immunohistochemistry and that a high concentration of intelectin-1 in pleural effusion can be used as a new marker for clinical diagnosis of MPM.

SUBMITTER: Tsuji S 

PROVIDER: S-EPMC2939784 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Publications

Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.

Tsuji S S   Tsuura Y Y   Morohoshi T T   Shinohara T T   Oshita F F   Yamada K K   Kameda Y Y   Ohtsu T T   Nakamura Y Y   Miyagi Y Y  

British journal of cancer 20100713 4


<h4>Background</h4>Malignant pleural mesothelioma (MPM) is a rare but fatal tumour. Although most MPM patients show pleural effusion at even the early stage, it is hard to diagnose as MPM at the early stage because a sensitive and reliable diagnostic marker for MPM has not been found in plasma or pleural effusion.<h4>Methods</h4>In this study, we investigated whether intelectin-1 was specifically contained in MPM cells and the pleural effusion of MPM patient by immunohistochemistry, western blot  ...[more]

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