Hyaluronic acid in viscous malignant mesothelioma pleural effusion.
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ABSTRACT:
SUBMITTER: Cheah HM
PROVIDER: S-EPMC7715921 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Hyaluronic acid in viscous malignant mesothelioma pleural effusion.
Cheah Hui Min HM Fitzgerald Deirdre D Louw Amber A Creaney Jenette J Lee Y C Gary YCG
Respirology case reports 20201203 1
Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity-dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (HA) content within the fluid. Treatment of the fluid with hyaluronidase, but not with deoxyribonucleases, significantly reduced fluid viscosity. The results provide proof that HA can contribute to high ...[more]
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