Ontology highlight
ABSTRACT:
SUBMITTER: Melhuish TA
PROVIDER: S-EPMC2939915 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Melhuish Tiffany A TA Chung David D DD Bjerke Glen A GA Wotton David D
Journal of cellular biochemistry 20101001 2
TG-interacting factor (Tgif1) represses gene expression by interaction with general corepressors, and can be recruited to target genes by transforming growth factor beta (TGFβ) activated Smads, or by the retinoid X receptor (RXR). Here we show that Tgif1 interacts with the LXRα nuclear receptor and can repress transcription from a synthetic reporter activated by LXRα. In cultured cells reducing endogenous Tgif1 levels resulted in increased expression of LXRα target genes. To test the in vivo rol ...[more]