BRCA1 represses amphiregulin gene expression.
Ontology highlight
ABSTRACT:
SUBMITTER: Lamber EP
PROVIDER: S-EPMC2816672 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
BRCA1 represses amphiregulin gene expression.
Lamber Ekaterina P EP Horwitz Andrew A AA Parvin Jeffrey D JD
Cancer research 20100126 3
BRCA1, the breast cancer- and ovarian cancer-specific tumor suppressor, can be a transcriptional repressor or a transcriptional activator, depending on the promoter context. To identify the genes activated or repressed by BRCA1, we have analyzed microarray results from cells depleted of BRCA1 and revealed a number of genes regulated by BRCA1 on the level of transcription. Among the genes repressed by BRCA1, we have identified amphiregulin (AREG) and early growth response-1 (EGR1). Results indica ...[more]
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