Ontology highlight
ABSTRACT:
SUBMITTER: Hancock AS
PROVIDER: S-EPMC2940466 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Hancock Aidan S AS Du Aiping A Liu Jingxuan J Miller Mayumi M May Catherine L CL
Molecular endocrinology (Baltimore, Md.) 20100630 8
The major role of glucagon is to promote hepatic gluconeogenesis and glycogenolysis to raise blood glucose levels during hypoglycemic conditions. Several animal models have been established to examine the in vivo function of glucagon in the liver through attenuation of glucagon via glucagon receptor knockout animals and pharmacological interventions. To investigate the consequences of glucagon loss to hepatic glucose production and glucose homeostasis, we derived mice with a pancreas specific ab ...[more]