Ontology highlight
ABSTRACT:
SUBMITTER: Wewer Albrechtsen NJ
PROVIDER: S-EPMC5695911 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cell reports 20171101 6
Glucagon is secreted from pancreatic α cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution-proteomics, we identified several glucagon variants, among which proglucagon 1-61 (PG 1-61) appears to be the most abundant form. PG 1-61 is secreted in subjects with obesity, both before and after gastric bypass surgery, with protein and fat as the main driv ...[more]