Ontology highlight
ABSTRACT:
SUBMITTER: Qiu Y
PROVIDER: S-EPMC2940714 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Qiu Yifu Y Mao Ting T Zhang Yongliang Y Shao Mengle M You Jia J Ding Qiurong Q Chen Yan Y Wu Dongmei D Xie Dong D Lin Xu X Gao Xiang X Kaufman Randal J RJ Li Wenjun W Liu Yong Y
Science signaling 20100126 106
Autophosphorylation of inositol-requiring enzyme 1alpha (IRE1alpha) is required for its activation, which elicits the cellular unfolded protein response (UPR) and is functionally connected with insulin biosynthesis in pancreatic beta cells. We found that the scaffold protein receptor for activated C-kinase 1 (RACK1) interacted with IRE1alpha in a glucose-stimulated or endoplasmic reticulum (ER) stress-responsive manner in pancreatic beta cells and primary islets. RACK1 mediated the glucose-induc ...[more]