Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC3128526 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Zhang Zhongyan Z Wakabayashi Nobunao N Wakabayashi Junko J Tamura Yasushi Y Song Woo-Jin WJ Sereda Sam S Clerc Pascaline P Polster Brian M BM Aja Susan M SM Pletnikov Mikhail V MV Kensler Thomas W TW Shirihai Orian S OS Iijima Miho M Hussain Mehboob A MA Sesaki Hiromi H
Molecular biology of the cell 20110505 13
Previous studies using in vitro cell culture systems have shown the role of the dynamin-related GTPase Opa1 in apoptosis prevention and mitochondrial DNA (mtDNA) maintenance. However, it remains to be tested whether these functions of Opa1 are physiologically important in vivo in mammals. Here, using the Cre-loxP system, we deleted mouse Opa1 in pancreatic beta cells, in which glucose-stimulated ATP production in mitochondria plays a key role in insulin secretion. Beta cells lacking Opa1 maintai ...[more]