Ontology highlight
ABSTRACT:
SUBMITTER: Shah P
PROVIDER: S-EPMC2940732 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Shah Premal P Gilchrist Michael A MA
PLoS genetics 20100916 9
Despite the fact that tRNA abundances are thought to play a major role in determining translation error rates, their distribution across the genetic code and the resulting implications have received little attention. In general, studies of codon usage bias (CUB) assume that codons with higher tRNA abundance have lower missense error rates. Using a model of protein translation based on tRNA competition and intra-ribosomal kinetics, we show that this assumption can be violated when tRNA abundances ...[more]