Ontology highlight
ABSTRACT:
SUBMITTER: Xiong S
PROVIDER: S-EPMC2940952 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Xiong Shunbin S Pant Vinod V Suh Young-Ah YA Van Pelt Carolyn S CS Wang Yongxing Y Valentin-Vega Yasmine A YA Post Sean M SM Lozano Guillermina G
Cancer research 20100824 18
High levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, suggesting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. To test this hypothesis in vivo, we generated transgenic mice with widespread expression of Mdm4. Two independent lines of transgenic mice, Mdm4(Tg1) and Mdm4(Tg15), developed spontaneous tumors, the most prevalent of which were sarcomas. To determine whether overexpression of Mdm4 also coop ...[more]