TRIM32 is a novel negative regulator of p53.
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ABSTRACT: To ensure proper function, the tumor suppressor p53 is tightly regulated through different post-translational modifications, particularly ubiquitination. Recently, TRIM32 was identified as a p53-regulated gene and an E3 ubiquitin ligase of p53. Thus, TRIM32 and p53 form a novel auto-regulatory negative feedback loop for p53 regulation in cells.
SUBMITTER: Liu J
PROVIDER: S-EPMC4904883 | biostudies-other | 2015 Apr-Jun
REPOSITORIES: biostudies-other
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