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TRIM32 is a novel negative regulator of p53.


ABSTRACT: To ensure proper function, the tumor suppressor p53 is tightly regulated through different post-translational modifications, particularly ubiquitination. Recently, TRIM32 was identified as a p53-regulated gene and an E3 ubiquitin ligase of p53. Thus, TRIM32 and p53 form a novel auto-regulatory negative feedback loop for p53 regulation in cells.

SUBMITTER: Liu J 

PROVIDER: S-EPMC4904883 | biostudies-other | 2015 Apr-Jun

REPOSITORIES: biostudies-other

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