Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC2941022 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Wang Liming L Nie Qing Q Enciso German G
Biophysical journal 20100901 6
Multisite phosphorylation is a common form of posttranslational protein regulation which has been used to increase the switchlike behavior of the protein response to increasing kinase concentrations. In this letter, we show that the switchlike response of multisite phosphoproteins is strongly enhanced by nonessential phosphorylation sites, a mechanism that is robust to parameter changes and easily implemented in nature. We obtained analytic estimates for the Hill exponent (or coefficient) of the ...[more]