Order statistics theory of unfolding of multimeric proteins.
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ABSTRACT:
SUBMITTER: Zhmurov A
PROVIDER: S-EPMC2941031 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Order statistics theory of unfolding of multimeric proteins.
Zhmurov A A Dima R I RI Barsegov V V
Biophysical journal 20100901 6
Dynamic force spectroscopy has become indispensable for the exploration of the mechanical properties of proteins. In force-ramp experiments, performed by utilizing a time-dependent pulling force, the peak forces for unfolding transitions in a multimeric protein (D)(N) are used to map the free energy landscape for unfolding for a protein domain D. We show that theoretical modeling of unfolding transitions based on combining the observed first (f(1)), second (f(2)), …, N(th) (f(N)) unfolding force ...[more]
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