Ontology highlight
ABSTRACT:
SUBMITTER: Chiang PM
PROVIDER: S-EPMC2941284 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Chiang Po-Min PM Ling Jonathan J Jeong Yun Ha YH Price Donald L DL Aja Susan M SM Wong Philip C PC
Proceedings of the National Academy of Sciences of the United States of America 20100726 37
Tat activating regulatory DNA-binding protein (Tardbp or TDP-43), a highly conserved metazoan DNA/RNA binding protein thought to be involved in RNA transcription and splicing, has been linked to the pathophysiology of amyotrophic lateral sclerosis and frontotemporal lobar degeneration and is essential for early embryonic development. However, neither the physiological role of TDP-43 in the adult nor its downstream targets are well defined. To address these questions, we developed conditional Tar ...[more]