Ontology highlight
ABSTRACT:
SUBMITTER: Llarrull LI
PROVIDER: S-EPMC2942778 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Llarrull Leticia I LI Prorok Mary M Mobashery Shahriar S
Biochemistry 20100901 37
The expression of the gene products in many methicillin-resistant Staphylococcus aureus (MRSA) strains is regulated by the gene repressor BlaI. Here we show that BlaI is a mixture of monomer and dimer at in vivo concentrations, binds to the operator regions preferentially as a monomeric protein, and the measured dissociation constants and in vivo concentrations account for the basal level transcription of the resistance genes. These observations for the first time provide a quantitative picture ...[more]