Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
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ABSTRACT:
SUBMITTER: Perry JR
PROVIDER: S-EPMC2942986 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
Perry John R B JR Stolk Lisette L Franceschini Nora N Lunetta Kathryn L KL Zhai Guangju G McArdle Patrick F PF Smith Albert V AV Aspelund Thor T Bandinelli Stefania S Boerwinkle Eric E Cherkas Lynn L Eiriksdottir Gudny G Estrada Karol K Ferrucci Luigi L Folsom Aaron R AR Garcia Melissa M Gudnason Vilmundur V Hofman Albert A Karasik David D Kiel Douglas P DP Launer Lenore J LJ van Meurs Joyce J Nalls Michael A MA Rivadeneira Fernando F Shuldiner Alan R AR Singleton Andrew A Soranzo Nicole N Tanaka Toshiko T Visser Jenny A JA Weedon Michael N MN Wilson Scott G SG Zhuang Vivian V Streeten Elizabeth A EA Harris Tamara B TB Murray Anna A Spector Tim D TD Demerath Ellen W EW Uitterlinden André G AG Murabito Joanne M JM
Nature genetics 20090517 6
We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation. ...[more]
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