Ontology highlight
ABSTRACT:
SUBMITTER: Lindgren CM
PROVIDER: S-EPMC2695778 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
PLoS genetics 20090626 6
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two ...[more]