Ontology highlight
ABSTRACT:
SUBMITTER: Dauber A
PROVIDER: S-EPMC2943098 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Dauber Andrew A Feldman Henry A HA Majzoub Joseph A JA
International journal of pediatric endocrinology 20100914
Classic congenital adrenal hyperplasia affects approximately 1 in 15,000 children. Current treatment strategies using multiple daily doses of hydrocortisone lead to suboptimal outcomes. We tested the hypothesis that nocturnal administration of dexamethasone will suppress the hypothalamic-pituitary-adrenal axis more effectively than standard hydrocortisone treatment by blocking the inherent diurnal secretion of ACTH. We performed a pilot study of five prepubertal patients comparing CAH control du ...[more]