Ontology highlight
ABSTRACT:
SUBMITTER: Apostol MI
PROVIDER: S-EPMC2943325 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Apostol Marcin I MI Sawaya Michael R MR Cascio Duilio D Eisenberg David D
The Journal of biological chemistry 20100804 39
A single nucleotide polymorphism (SNP) in codon 129 of the human prion gene, leading to a change from methionine to valine at residue 129 of prion protein (PrP), has been shown to be a determinant in the susceptibility to prion disease. However, the molecular basis of this effect remains unexplained. In the current study, we determined crystal structures of prion segments having either Met or Val at residue 129. These 6-residue segments of PrP centered on residue 129 are "steric zippers," pairs ...[more]