Ontology highlight
ABSTRACT:
SUBMITTER: Chao MP
PROVIDER: S-EPMC2943345 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Chao Mark P MP Alizadeh Ash A AA Tang Chad C Myklebust June H JH Varghese Bindu B Gill Saar S Jan Max M Cha Adriel C AC Chan Charles K CK Tan Brent T BT Park Christopher Y CY Zhao Feifei F Kohrt Holbrook E HE Malumbres Raquel R Briones Javier J Gascoyne Randy D RD Lossos Izidore S IS Levy Ronald R Weissman Irving L IL Majeti Ravindra R
Cell 20100901 5
Monoclonal antibodies are standard therapeutics for several cancers including the anti-CD20 antibody rituximab for B cell non-Hodgkin lymphoma (NHL). Rituximab and other antibodies are not curative and must be combined with cytotoxic chemotherapy for clinical benefit. Here we report the eradication of human NHL solely with a monoclonal antibody therapy combining rituximab with a blocking anti-CD47 antibody. We identified increased expression of CD47 on human NHL cells and determined that higher ...[more]