Ontology highlight
ABSTRACT:
SUBMITTER: Schulte JH
PROVIDER: S-EPMC2943620 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Schulte Johannes H JH Marschall Tobias T Martin Marcel M Rosenstiel Philipp P Mestdagh Pieter P Schlierf Stefanie S Thor Theresa T Vandesompele Jo J Eggert Angelika A Schreiber Stefan S Rahmann Sven S Schramm Alexander A
Nucleic acids research 20100513 17
Small non-coding RNAs, in particular microRNAs(miRNAs), regulate fine-tuning of gene expression and can act as oncogenes or tumor suppressor genes. Differential miRNA expression has been reported to be of functional relevance for tumor biology. Using next-generation sequencing, the unbiased and absolute quantification of the small RNA transcriptome is now feasible. Neuroblastoma(NB) is an embryonal tumor with highly variable clinical course. We analyzed the small RNA transcriptomes of five favor ...[more]