Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Donas J
PROVIDER: S-EPMC5033860 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
García-Donas Jesús J Beuselinck Benoit B Inglada-Pérez Lucía L Graña Osvaldo O Schöffski Patrick P Wozniak Agnieszka A Bechter Oliver O Apellániz-Ruiz Maria M Leandro-García Luis Javier LJ Esteban Emilio E Castellano Daniel E DE González Del Alba Aranzazu A Climent Miguel Angel MA Hernando Susana S Arranz José Angel JA Morente Manuel M Pisano David G DG Robledo Mercedes M Rodriguez-Antona Cristina C
JCI insight 20160707 10
The majority of metastatic renal cell carcinoma (RCC) patients are treated with tyrosine kinase inhibitors (TKI) in first-line treatment; however, a fraction are refractory to these antiangiogenic drugs. MicroRNAs (miRNAs) are regulatory molecules proven to be accurate biomarkers in cancer. Here, we identified miRNAs predictive of progressive disease under TKI treatment through deep sequencing of 74 metastatic clear cell RCC cases uniformly treated with these drugs. Twenty-nine miRNAs were diffe ...[more]