Ontology highlight
ABSTRACT:
SUBMITTER: Blaise M
PROVIDER: S-EPMC2944067 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Blaise Mickaël M Bailly Marc M Frechin Mathieu M Behrens Manja Annette MA Fischer Frédéric F Oliveira Cristiano L P CL Becker Hubert Dominique HD Pedersen Jan Skov JS Thirup Søren S Kern Daniel D
The EMBO journal 20100817 18
Four out of the 22 aminoacyl-tRNAs (aa-tRNAs) are systematically or alternatively synthesized by an indirect, two-step route requiring an initial mischarging of the tRNA followed by tRNA-dependent conversion of the non-cognate amino acid. During tRNA-dependent asparagine formation, tRNA(Asn) promotes assembly of a ribonucleoprotein particle called transamidosome that allows channelling of the aa-tRNA from non-discriminating aspartyl-tRNA synthetase active site to the GatCAB amidotransferase site ...[more]