Ontology highlight
ABSTRACT:
SUBMITTER: Coburn K
PROVIDER: S-EPMC5379170 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Coburn Katherine K Melville Zephan Z Aligholizadeh Ehson E Roth Braden M BM Varney Kristen M KM Carrier France F Pozharski Edwin E Weber David J DJ
Acta crystallographica. Section F, Structural biology communications 20170322 Pt 4
The heterogeneous ribonucleoprotein A18 (hnRNP A18) is upregulated in hypoxic regions of various solid tumors and promotes tumor growth via the coordination of mRNA transcripts associated with pro-survival genes. Thus, hnRNP A18 represents an important therapeutic target in tumor cells. Presented here is the first X-ray crystal structure to be reported for the RNA-recognition motif of hnRNP A18. By comparing this structure with those of homologous RNA-binding proteins (i.e. hnRNP A1), three resi ...[more]