Ontology highlight
ABSTRACT:
SUBMITTER: Fidock DA
PROVIDER: S-EPMC2944663 | biostudies-literature | 2000 Oct
REPOSITORIES: biostudies-literature
Molecular cell 20001001 4
The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors a 13-exon gene, pfcrt, having point mutations that associate completely with CQR in parasite lines from Asia, Africa, and South America. These data, transfection results, and selection of a CQR line harboring a novel K761 mutation point to a central role for the PfCRT protein in CQR. This transmembrane protein localizes to the ...[more]