Ontology highlight
ABSTRACT:
SUBMITTER: Kusy S
PROVIDER: S-EPMC2947082 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Kusy Sophie S Gerby Bastien B Goardon Nicolas N Gault Nathalie N Ferri Federica F Gérard Delphine D Armstrong Florence F Ballerini Paola P Cayuela Jean-Michel JM Baruchel André A Pflumio Françoise F Roméo Paul-Henri PH
The Journal of experimental medicine 20100920 10
TAL1 (also known as SCL) is expressed in >40% of human T cell acute lymphoblastic leukemias (T-ALLs). TAL1 encodes a basic helix-loop-helix transcription factor that can interfere with the transcriptional activity of E2A and HEB during T cell leukemogenesis; however, the oncogenic pathways directly activated by TAL1 are not characterized. In this study, we show that, in human TAL1-expressing T-ALL cell lines, TAL1 directly activates NKX3.1, a tumor suppressor gene required for prostate stem cell ...[more]