TLR8 deficiency leads to autoimmunity in mice.
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ABSTRACT:
SUBMITTER: Demaria O
PROVIDER: S-EPMC2947223 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
TLR8 deficiency leads to autoimmunity in mice.
Demaria Olivier O Pagni Philippe P PP Traub Stephanie S de Gassart Aude A Branzk Nora N Murphy Andrew J AJ Valenzuela David M DM Yancopoulos George D GD Flavell Richard A RA Alexopoulou Lena L
The Journal of clinical investigation 20100901 10
TLRs play an essential role in the induction of immune responses by detecting conserved molecular products of microorganisms. However, the function of TLR8 is largely unknown. In the current study, we investigated the role of TLR8 signaling in immunity in mice. We found that Tlr8(-/-) DCs overexpressed TLR7, were hyperresponsive to various TLR7 ligands, and showed stronger and faster NF-κB activation upon stimulation with the TLR7 ligand R848. Tlr8(-/-) mice showed splenomegaly, defective develo ...[more]
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