Ontology highlight
ABSTRACT:
SUBMITTER: Desnues B
PROVIDER: S-EPMC3910605 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Desnues Benoit B Macedo Amanda Beatriz AB Roussel-Queval Annie A Bonnardel Johnny J Henri Sandrine S Demaria Olivier O Alexopoulou Lena L
Proceedings of the National Academy of Sciences of the United States of America 20140113 4
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with diverse clinical presentations characterized by the presence of autoantibodies to nuclear components. Toll-like receptor (TLR)7, TLR8, and TLR9 sense microbial or endogenous nucleic acids and are implicated in the development of SLE. In mice TLR7-deficiency ameliorates SLE, but TLR8- or TLR9-deficiency exacerbates the disease because of increased TLR7 response. Thus, both TLR8 and TLR9 control TLR7 function, but whether TLR8 ...[more]