Ontology highlight
ABSTRACT:
SUBMITTER: Dikeakos JD
PROVIDER: S-EPMC2947465 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Dikeakos Jimmy D JD Atkins Katelyn M KM Thomas Laurel L Emert-Sedlak Lori L Byeon In-Ja L IJ Jung Jinwon J Ahn Jinwoo J Wortman Matthew D MD Kukull Ben B Saito Masumichi M Koizumi Hirokazu H Williamson Danielle M DM Hiyoshi Masateru M Barklis Eric E Takiguchi Masafumi M Suzu Shinya S Gronenborn Angela M AM Smithgall Thomas E TE Thomas Gary G
Molecular biology of the cell 20100811 19
HIV-1 Nef triggers down-regulation of cell-surface MHC-I by assembling a Src family kinase (SFK)-ZAP-70/Syk-PI3K cascade. Here, we report that chemical disruption of the Nef-SFK interaction with the small molecule inhibitor 2c blocks assembly of the multi-kinase complex and represses HIV-1-mediated MHC-I down-regulation in primary CD4(+) T-cells. 2c did not interfere with the PACS-2-dependent trafficking of Nef required for the Nef-SFK interaction or the AP-1 and PACS-1-dependent sequestering of ...[more]