A novel Pzg-NURF complex regulates Notch target gene activity.
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ABSTRACT:
SUBMITTER: Kugler SJ
PROVIDER: S-EPMC2947479 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
A novel Pzg-NURF complex regulates Notch target gene activity.
Kugler Sabrina J SJ Nagel Anja C AC
Molecular biology of the cell 20100804 19
Drosophila putzig was identified as a member of the TRF2-DREF complex that is involved in core promoter selection. Additionally, putzig regulates Notch signaling, however independently of DREF. Here, we show that Putzig associates with the NURF complex. Loss of any NURF component including the NURF-specific subunit Nurf 301 impedes binding of Putzig to Notch target genes, suggesting that NURF recruits Putzig to these sites. Accordingly, Putzig can be copurified with any NURF member. Moreover, Nu ...[more]
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