Ontology highlight
ABSTRACT:
SUBMITTER: Mulligan P
PROVIDER: S-EPMC3119599 | biostudies-other | 2011 Jun
REPOSITORIES: biostudies-other
Mulligan Peter P Yang Fajun F Di Stefano Luisa L Ji Jun-Yuan JY Ouyang Jian J Nishikawa Joy L JL Toiber Debra D Kulkarni Madhura M Wang Qun Q Najafi-Shoushtari S Hani SH Mostoslavsky Raul R Gygi Steven P SP Gill Grace G Dyson Nicholas J NJ Näär Anders M AM
Molecular cell 20110519 5
Epigenetic regulation of gene expression by histone-modifying corepressor complexes is central to normal animal development. The NAD(+)-dependent deacetylase and gene repressor SIRT1 removes histone H4K16 acetylation marks and facilitates heterochromatin formation. However, the mechanistic contribution of SIRT1 to epigenetic regulation at euchromatic loci and whether it acts in concert with other chromatin-modifying activities to control developmental gene expression programs remain unclear. We ...[more]