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Enhanced uptake of porous silica microparticles by bifunctional surface modification with a targeting antibody and a biocompatible polymer.

ABSTRACT: Strategies were developed by which mesoporous microparticles were modified on their external surfaces with tetraethylene glycol (TEG), a protein, or both, leaving the pore surfaces available for modification with a separate moiety, such as a dye. Only particles bifunctionally modified with both TEG and a cell-specific antibody were taken up specifically by a targeted cancer cell line. In contrast to similarly functionalized nanoparticles, endocytosed microparticles were not contained within a lysosome.

SUBMITTER: Cheng K

PROVIDER: S-EPMC2947489 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Enhanced uptake of porous silica microparticles by bifunctional surface modification with a targeting antibody and a biocompatible polymer.

Cheng Kai K Blumen Steven R SR MacPherson Maximilian B MB Steinbacher Jeremy L JL Mossman Brooke T BT Landry Christopher C CC

ACS applied materials & interfaces 20100901 9

Strategies were developed by which mesoporous microparticles were modified on their external surfaces with tetraethylene glycol (TEG), a protein, or both, leaving the pore surfaces available for modification with a separate moiety, such as a dye. Only particles bifunctionally modified with both TEG and a cell-specific antibody were taken up specifically by a targeted cancer cell line. In contrast to similarly functionalized nanoparticles, endocytosed microparticles were not contained within a ly ...[more]

PMID: 20707315

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