Unknown

Dataset Information

0

Estimated cumulative incidence of pandemic (H1N1) influenza among pregnant women during the first wave of the 2009 pandemic.


ABSTRACT:

Background

Hospitalization and lab confirmed cases of H1N1 have been reported during the first wave of the 2009 pandemic but these are not accurate measures of influenza incidence in the population. We estimated the cumulative incidence of pandemic (H1N1) influenza among pregnant women in the province of Manitoba during the first wave of the 2009 pandemic.

Methods

Two panels of stored frozen serum specimens collected for routine prenatal screening were randomly selected for testing before (March 2009, n = 252) and after (August 2009, n = 296) the first wave of the pandemic. A standard hemagglutination inhibition assay was used to detect the presence of IgG antibodies against the pandemic (H1N1) 2009 virus. The cumulative incidence of pandemic (H1N1) influenza was calculated as the difference between the point prevalence rates in the first and second panels.

Results

Of the specimens collected in March, 7.1% were positive for the IgG antibodies (serum antibody titre ? 1:40). The corresponding prevalence was 15.7% among the specimens collected in August. The difference indicated a cumulative incidence of 8.6% (95% confidence interval [CI] 3.2%-13.7%). The rate differed geographically, the highest being in the northern regions (20.8%, 95% CI 7.9%-31.8%), as compared with 4.0% (95% CI 0.0%-11.9%) in Winnipeg and 8.9% (95% CI 0.0%-18.8%) in the rest of the province.

Interpretation

We estimated that the cumulative incidence of pandemic (H1N1) influenza among pregnant women in Manitoba during the first wave of the 2009 pandemic was 8.6%. It was 20.8% in the northern regions of the province.

SUBMITTER: Mahmud SM 

PROVIDER: S-EPMC2950183 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Estimated cumulative incidence of pandemic (H1N1) influenza among pregnant women during the first wave of the 2009 pandemic.

Mahmud Salaheddin M SM   Becker Marissa M   Keynan Yoav Y   Elliott Lawrence L   Thompson Laura H LH   Fowke Keith K   Avery Lisa L   Van Caeseele Paul P   Harlos Sande S   Blanchard James J   Dawood Magdy M  

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20100907 14


<h4>Background</h4>Hospitalization and lab confirmed cases of H1N1 have been reported during the first wave of the 2009 pandemic but these are not accurate measures of influenza incidence in the population. We estimated the cumulative incidence of pandemic (H1N1) influenza among pregnant women in the province of Manitoba during the first wave of the 2009 pandemic.<h4>Methods</h4>Two panels of stored frozen serum specimens collected for routine prenatal screening were randomly selected for testin  ...[more]

Similar Datasets

| S-EPMC2828126 | biostudies-literature
| S-EPMC3151238 | biostudies-literature
| S-EPMC3294965 | biostudies-literature
| S-EPMC3792731 | biostudies-literature
| S-EPMC2904390 | biostudies-literature
| S-EPMC5781221 | biostudies-literature
| S-EPMC6708558 | biostudies-literature
| S-EPMC2905828 | biostudies-literature
| S-EPMC2964451 | biostudies-other
| S-EPMC3572103 | biostudies-other