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ABSTRACT:
SUBMITTER: Hernaez B
PROVIDER: S-EPMC2950572 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Hernáez Bruno B Tarragó Teresa T Giralt Ernest E Escribano Jose M JM Alonso Covadonga C
Journal of virology 20100804 20
Several viruses target the microtubular motor system in early stages of the viral life cycle. African swine fever virus (ASFV) protein p54 hijacks the microtubule-dependent transport by interaction with a dynein light chain (DYNLL1/DLC8). This was shown to be a high-affinity interaction, and the residues gradually disappearing were mapped on DLC8 to define a putative p54 binding surface by nuclear magnetic resonance (NMR) spectroscopy. The potential of short peptides targeting the binding domain ...[more]