Ontology highlight
ABSTRACT:
SUBMITTER: Firestone AJ
PROVIDER: S-EPMC3321072 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Firestone Ari J AJ Weinger Joshua S JS Maldonado Maria M Barlan Kari K Langston Lance D LD O'Donnell Michael M Gelfand Vladimir I VI Kapoor Tarun M TM Chen James K JK
Nature 20120318 7392
The conversion of chemical energy into mechanical force by AAA+ (ATPases associated with diverse cellular activities) ATPases is integral to cellular processes, including DNA replication, protein unfolding, cargo transport and membrane fusion. The AAA+ ATPase motor cytoplasmic dynein regulates ciliary trafficking, mitotic spindle formation and organelle transport, and dissecting its precise functions has been challenging because of its rapid timescale of action and the lack of cell-permeable, ch ...[more]