Ontology highlight
ABSTRACT:
SUBMITTER: Palacios D
PROVIDER: S-EPMC2951277 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Palacios Daniela D Mozzetta Chiara C Consalvi Silvia S Caretti Giuseppina G Saccone Valentina V Proserpio Valentina V Marquez Victor E VE Valente Sergio S Mai Antonello A Forcales Sonia V SV Sartorelli Vittorio V Puri Pier Lorenzo PL
Cell stem cell 20101001 4
How regeneration cues are converted into the epigenetic information that controls gene expression in adult stem cells is currently unknown. We identified an inflammation-activated signaling in muscle stem (satellite) cells, by which the polycomb repressive complex 2 (PRC2) represses Pax7 expression during muscle regeneration. TNF-activated p38α kinase promotes the interaction between YY1 and PRC2, via threonine 372 phosphorylation of EZH2, the enzymatic subunit of the complex, leading to the for ...[more]