Ontology highlight
ABSTRACT:
SUBMITTER: Rosales XQ
PROVIDER: S-EPMC3634894 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Rosales Xiomara Q XQ Malik Vinod V Sneh Amita A Chen Lei L Lewis Sarah S Kota Janaiah J Gastier-Foster Julie M JM Astbury Caroline C Pyatt Rob R Reshmi Shalini S Rodino-Klapac Louise R LR Clark K Reed KR Mendell Jerry R JR Sahenk Zarife Z
Muscle & nerve 20130329 5
<h4>Introduction</h4>Recent in vitro studies suggest that CAPN3 deficiency leads initially to accelerated myofiber formation followed by depletion of satellite cells (SC). In normal muscle, up-regulation of miR-1 and miR-206 facilitates transition from proliferating SCs to differentiating myogenic progenitors.<h4>Methods</h4>We examined the histopathological stages, Pax7 SC content, and muscle-specific microRNA expression in biopsy specimens from well-characterized LGMD 2A patients to gain insig ...[more]