Ontology highlight
ABSTRACT:
SUBMITTER: Paul SB
PROVIDER: S-EPMC2951703 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Paul Satya B SB Choudhury Sudip S
Bioinformation 20100430 10
TtgR is a multi-drug binding protein in the gram negative bacteria Pseudomonas putida (DOT-T1E strain) and regulates one of the key mechanisms of its antibiotic resistance by active extrusion of toxic compounds through the membrane-bound efflux pumps. The paper reports the molecular docking studies of Pongachalcone I, a natural pyranochalcone and reported potent inhibitor of the bacteria, on the transcriptional regulator (TtgR) enzyme (PDB Code: 2UXI) which is a key efflux pump TtgABC operon rep ...[more]