Ontology highlight
ABSTRACT:
SUBMITTER: Nagarajan D
PROVIDER: S-EPMC5846155 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nagarajan Deepesh D Nagarajan Tushar T Roy Natasha N Kulkarni Omkar O Ravichandran Sathyabaarathi S Mishra Madhulika M Chakravortty Dipshikha D Chandra Nagasuma N
The Journal of biological chemistry 20171219 10
There is a pressing need for new therapeutics to combat multidrug- and carbapenem-resistant bacterial pathogens. This challenge prompted us to use a long short-term memory (LSTM) language model to understand the underlying grammar, <i>i.e.</i> the arrangement and frequencies of amino acid residues, in known antimicrobial peptide sequences. According to the output of our LSTM network, we synthesized 10 peptides and tested them against known bacterial pathogens. All of these peptides displayed bro ...[more]