Computational identification of post-translational modification sites and functional families reveal possible moonlighting role of rotaviral proteins.

ABSTRACT: Rotavirus (RV) diarrhoea causes huge number deaths in children less than 5 years of age. In spite of available vaccines, it has been difficult to combat RV due to large number of antigenically distinct genotypes, high mutation rates, generation of reassortant viruses due to segmented genome. RV is an eukaryotic virus which utilizes host cell machinery for its propagation. Since RV only encodes 12 proteins, post-translational modification (PTM) is important mechanism for modification, which consequently alters their function. A single protein exhibiting different functions in different locations or in different subcellular sites, are known to be 'moonlighting'. So there is a possibility that viral proteins moonlight in separate location and in different time to exhibit diverse cellular effe

SUBMITTER: Chattopadhyay S 

PROVIDER: S-EPMC2951707 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature