Ontology highlight
ABSTRACT:
SUBMITTER: Naqvi A
PROVIDER: S-EPMC2951863 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Naqvi Asma A Hoffman Timothy A TA DeRicco Jeremy J Kumar Ajay A Kim Cuk-Seong CS Jung Saet-Byel SB Yamamori Tohru T Kim Young-Rae YR Mehdi Fardeen F Kumar Santosh S Rankinen Tuomo T Ravussin Eric E Irani Kaikobad K
Human molecular genetics 20100806 21
The SIRTUIN1 (SIRT1) deacetylase responds to changes in nutrient availability and regulates mammalian physiology and metabolism. Human and mouse SIRT1 are transcriptionally repressed by p53 via p53 response elements in their proximal promoters. Here, we identify a novel p53-binding sequence in the distal human SIRT1 promoter that is required for nutrient-sensitive SIRT1 transcription. In addition, we show that a common single-nucleotide (C/T) variation in this sequence affects nutrient deprivati ...[more]