Ontology highlight
ABSTRACT:
SUBMITTER: Fooksman DR
PROVIDER: S-EPMC2952879 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Fooksman David R DR Schwickert Tanja A TA Victora Gabriel D GD Dustin Michael L ML Nussenzweig Michel C MC Skokos Dimitris D
Immunity 20100708 1
In this study, we imaged the differentiation and migratory behavior of nascent plasma cells (PCs) in mouse lymph nodes by intravital microscopy. Pre-PCs exhibited a unique migration pattern characterized by long, linear paths that were randomly oriented. Although chemotaxis via Galphai coupled-receptors has been implicated in PC migration, treatment with Pertussis toxin (Ptx), which ablates these signals, did not prevent movement of pre-PCs while it arrested other lymphocytes. In vitro, pre-PCs ...[more]